Prednisone for Pets

Prednisone is a synthetic steroid that the body converts to prednisolone in the liver. It helps decrease inflammation and can suppress certain immune system responses. Veterinarians may prescribe it for allergic conditions, itchy skin disease, inflammatory bowel disease, some respiratory conditions, immune-mediated disease, Addison's disease, and as part of treatment plans for certain cancers. In dogs, oral prednisone is commonly used for chronic inflammatory conditions. In cats, prednisolone is often preferred because cats do not efficiently convert prednisone to prednisolone.

Common side effects can include: • Increased thirst • Increased urination • Increased appetite • Panting • Mild vomiting or diarrhea • Mild behavior changes or restlessness

More serious concerns can include: • Black, tarry, or bloody stools • Vomiting blood • Severe weakness or collapse • Marked lethargy • Muscle wasting or pot-bellied appearance with long-term use • Hair coat changes • Signs of infection such as fever or worsening illness • Signs of diabetes such as weight loss despite a good appetite, plus increased thirst and urination

The risk and severity of side effects generally increase with higher doses and longer treatment.

Always follow your vet's instructions exactly. Give prednisone with food unless your veterinarian tells you otherwise, and measure liquid forms carefully. Do not stop this medication suddenly unless your veterinarian specifically says it is safe to do so, because steroids often need to be tapered gradually. If your pet misses a dose, give it when you remember unless it is almost time for the next dose; then skip the missed dose and return to the regular schedule. Never give two doses at once. Tell your vet about any other medications or supplements your pet takes, especially NSAIDs such as carprofen, meloxicam, or aspirin, because combining these drugs can increase the risk of stomach ulcers and other complications.