Ursodiol for Pets
Ursodiol is a bile acid medication veterinarians may prescribe for dogs and cats with certain liver and gallbladder conditions. It can help improve bile flow and reduce the harmful effects of some bile acids, but it should only be used under veterinary guidance.
Ursodiol Quick Facts
Drug class
Bile acid; hepatobiliary medication.
Common brand names
Actigall, Urso, Urso Forte; generic ursodiol.
Common forms
Tablets, capsules, and compounded liquid formulations.
Species used in
Dogs and cats, by veterinary prescription.
What Ursodiol Is Used For
Ursodiol, also called ursodeoxycholic acid, is a naturally occurring bile acid used in veterinary medicine for selected liver and biliary tract disorders. Veterinarians may prescribe it to help increase bile flow, reduce the toxic effects of certain bile acids, and support pets with some chronic hepatobiliary diseases. In small animals, reported uses include some cases of chronic hepatitis, idiopathic hepatic lipidosis, and cholesterol-containing gallstones. It is generally considered better established in dogs, though it is also used in cats in appropriate cases. Ursodiol is not appropriate for every liver or gallbladder problem, and pets with biliary obstruction or certain complications may need different treatment, so your veterinarian should confirm that it is safe for your pet.
Side Effects to Watch For
Ursodiol is generally well tolerated, but side effects can occur. Common side effects may include mild stomach upset such as vomiting, diarrhea, reduced appetite, or soft stools. Contact your veterinarian promptly if side effects are persistent, if your pet seems painful or lethargic, or if symptoms worsen after starting the medication. More serious concerns can include signs that may suggest an allergic reaction or a complication related to the underlying liver or biliary disease, such as facial swelling, hives, trouble breathing, collapse, worsening vomiting, jaundice, or marked abdominal pain. Call your vet right away if you notice any of these signs.
Dosing & Administration
Always follow your vet's instructions for how and when to give ursodiol. This medication is commonly given by mouth, and veterinary references note it is often administered with food. Give it exactly as prescribed and do not change the amount, schedule, or formulation unless your veterinarian tells you to. If your pet is receiving a compounded liquid, measure each dose carefully using the device provided by your pharmacy. Tell your veterinarian about any other medications or supplements your pet takes, because some products, including certain antacids, may interfere with how ursodiol works. Keep all recommended recheck appointments so your vet can monitor liver values and response to treatment.
When to Call a Vet
Go to the ER now
- ● Signs of an allergic reaction, such as facial swelling, hives, severe itching, trouble breathing, or collapse.
- ● Possible overdose or medication error, especially if your pet received too much or got into the bottle.
- ● Severe vomiting, severe diarrhea, extreme weakness, collapse, or severe abdominal pain.
See a vet within 24 hours
- ● Persistent vomiting, diarrhea, poor appetite, or stomach upset after starting ursodiol.
- ● Yellowing of the eyes, gums, or skin, or worsening signs of liver disease.
- ● Your pet seems more lethargic, painful, or unwell while taking the medication.
Watch at home, call if it worsens
- ● Mild, short-lived stomach upset that resolves quickly.
- ● Questions about giving the medication with meals or a missed dose.
- ● Any change that is mild but not clearly improving—when in doubt, call your vet.
Frequently Asked Questions
Can I give my dog human ursodiol?
What happens if I miss a dose?
Can my cat take ursodiol?
Should ursodiol be given with food?
How long will my pet need to take ursodiol?
Disclaimer: The information provided in this article is for educational purposes only and does not constitute veterinary medical advice. Reading this content does not establish a veterinarian-client-patient relationship. Every pet is different — always consult a licensed veterinarian before making decisions about your pet's health, diet, or care. If you'd like personalized guidance, you can talk to one of our vets. If your pet is experiencing a medical emergency, contact your local emergency animal hospital immediately.